Senior Scientist, Clinical Bioinformatics

Introduction to role:

The Senior Scientist joining our Clinical Bioinformatics group will be at the forefront of maximizing advanced statistical and bioinformatics techniques to develop and apply innovative ways to clinical data analysis, with a particular focus on proteomics and transcriptomics. This role is pivotal in our efforts within Translational Medicine, striving to harness the power of multi-omics integration to uncover novel biomarkers and pathways that are critical for understanding the response to therapy in rare diseases across a spectrum of therapeutic areas, including Hematology, Nephrology, Neuroscience, Cardiovascular, Metabolic Diseases, and rare Oncology.

Accountabilities:

The successful candidate will be instrumental in constructing sophisticated workflows and applying innovative algorithms to analyze clinical multi-omics data. This includes the development of visualization tools tailored for the intricate interpretation of proteomics data, providing comprehensive analytical support for omics study design in close collaboration with clinical, biomarker, and translational groups. A key aspect of this role involves the integration of proteomics data with other omics datasets, synthesizing complex information into actionable insights and clear, concise recommendations for our collaborators.

As a great teammate with a critical eye for data analysis and interpretation, the candidate will contribute to the design and analysis of clinical trials, employing advanced biostatistical methods to ensure the statistical rigor and clinical relevance of our studies. This role also includes contributing to the delivery of Clinical Study Reports (CSRs), regulatory submissions, and the development of standard processes aimed at enhancing the quality, efficiency, and effectiveness of the Clinical Bioinformatics group. Through these efforts, the Senior Scientist will play a crucial role in advancing our understanding of rare diseases and contributing to the development of novel therapeutic strategies.

Essential Skills/Experience:

• Ph.D. in Bioinformatics, Computational Biology, Biostatistics, or a closely related field, complemented by post-doctoral experience in a relevant area.
• Minimum of 2 years of post-PhD experience in pharma/biotech industry, in bioinformatics and/or biostatistics for target identification, biomarkers of response and -omics patient’s profiling.
• Advanced computational skills and experience in designing and running data analyses in a cloud environment.
• Statistical Expertise: Deep understanding of statistical methods used in clinical data analysis, with a proven track record of applying these techniques to biological data. Familiarity with software such as R is essential (SAS, or SPSS optional).
• Multi-Omics Proficiency: Extensive experience in the analysis of multi-omics data, including genomics, transcriptomics, proteomics, and metabolomics, with a strong grasp of the underlying statistical principles.
• Technical Skills: Proficiency in programming languages (e.g., R, Python) and experience with bioinformatics tools and databases. Ability to handle large datasets and perform complex data analyses.
• Communication Skills: Outstanding ability to communicate statistical concepts and findings to diverse audiences, coupled with strong publication and presentation skills.

Desirable Skills/Experience:

• Exposure to network biology, knowledge graphs, graph ML and computational drug design is desired but not required.
• Clinical Trials Experience: Demonstrated experience/exposure in the statistical aspects of clinical trial design, execution, and analysis. Awareness of regulatory requirements and guidelines for clinical research is a plus.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world!

Joining Alexion means embracing an opportunity where work isn’t ordinary. We are a beacon in the global Biopharmaceutical landscape. Our closeness to patients brings us closer to our work and each other. Combined with our brave, pioneering spirit – we are truly unique in R&D and healthcare. At Alexion, grow and innovate in a business with a rapidly expanding portfolio. Enjoy the entrepreneurial spirit and autonomy of a leading biotech while meeting the needs of some of the most under-served patients in the world. You will be empowered with tailored development programs designed not just for skill enhancement but for fostering a deep understanding of our patient's journeys. Here, your career is not just a path but a journey to making a difference where it truly counts.

Ready to make an impact? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.