Enterprise Productivity Office Lead

Purpose

The Global Productivity Initiatives Lead shapes and drives Alexion’s enterprise productivity agenda through the Enterprise Productivity Office (EPO). The role aligns cross-functional productivity and transformation initiatives to optimize resources, processes, and capabilities in support of Alexion AstraZeneca Rare Disease’s corporate priorities and ambition.

Key Accountabilities

• Enterprise Productivity Strategy & Governance: Own and evolve the enterprise productivity strategy aligned to corporate and Alexion Leadership Team (ALT) priorities. Secure ALT and stakeholder alignment on scope, outcomes, funding, and resourcing.

• Strategic Enablement: Lead core EPO focus areas: (1) Global Footprint Optimization (2) Technology & Innovation (3) Automation & Insourcing (4) Centralization.

• Initiative Leadership: Identify efficiency opportunities and lead enterprise-critical initiatives managed by EPO in partnership with the business. Support business-led initiatives that require enterprise alignment, a consistent methodology, or acceleration.

• Cross Functional Engagement & Change Enablement: Partner with global and functional leaders to embed productivity into ways of working and business planning. Foster a culture of innovation, smart risk-taking, and experimentation.

• Financial Impact & Reinvestment Enablement: Ensure initiatives deliver tangible financial impact (e.g., cost savings, margin protection, capacity release). Build business cases with defined financial and impact KPIs and track benefits through implementation.

Scope and Interfaces

• Internal stakeholders: Alexion CEO, CFO, SVP HR, Head of IT, and ALT members • External partners: vendors and partners needed to execute productivity initiatives

• Primary customers/users: AstraZeneca enterprise functions

Deliverables

• Shaping enterprise productivity strategy: Partner with Alexion executive leadership to shape and drive a strategy that delivers enterprise productivity across rare disease functions using multiple business levers.

Delivery of assigned EPO initiatives: Deliver EPO initiatives by defining and planning new work, engaging cross-functional teams, and driving on-time milestones. Prioritize initiatives and track benefits vs. baseline (e.g., cost savings, efficiency gains, cycle-time reduction).

• Governance: Lead the EPO SteerCo and other steering/working groups; manage decisions and risks; and deliver executive-ready communications and status reporting.

• Change and adoption outcomes: Partner with HR on change impact assessments, training, communications, and adoption tracking (e.g., completion rates, usage metrics, process compliance) to embed new ways of working.

• Portfolio pipeline support: Maintain the initiative pipeline, prioritization, and quarterly planning updates, recommending improvements to sequencing and resourcing.

• Continuous improvement of EPO ways of working: Continuously improve alignment and impact through templates, dashboards, and delivery playbooks. Capture lessons learned and strengthen predictability, transparency, and delivery efficiency.

Qualifications

• Advanced degree in business, life sciences, engineering, data science, or related field; PhD or MS preferred.

• 10+ years’ experience in pharma/biotech or a related industry, leading enterprise-level initiatives with proven cross-functional delivery.

• Experience implementing AI, digital, or data-driven solutions.

• Strong program leadership, vendor management, and cross-functional influence at senior levels; change management and operating model design experience.

• Essential: Experience leading enterprise-wide projects, transformation, or operating model initiatives.

• Proven ability to operate at executive level, influencing prioritization and investment decisions with strong communication skills.

• Strong track record delivering measurable productivity, cost, or efficiency outcomes.

• Enterprise strategy, portfolio, and project management.

• Productivity and operating model design expertise.

Success Profile

• Structured, outcome-focused enterprise leader who drives clarity, pace, and accountability across ambiguous, cross-functional work.

• Trusted partner and communicator who can influence senior stakeholders, facilitate decisions, and manage competing priorities in a matrix.

• Change agent with a pragmatic approach to adoption—balances process discipline with continuous improvement and user-centric ways of working.

Travel

Travel to key hubs and sites as required.

Why Join Alexion Enterprise Productivity Office?

The EPO plays a critical role in enabling Alexion to achieve its 2030 Bold Ambition by driving enterprise-wide productivity, innovation, and operational excellence. As a Project Manager in the EPO, you will have the opportunity to:

• Make a tangible impact on Alexion’s strategic priorities and financial performance.

• Work on high-visibility initiatives that shape the future of the organization.

• Collaborate with senior leaders across Global, International, and Functional teams.

• Develop your career in a dynamic, fast-paced environment that values innovation, smart risk-taking, and continuous improvement.

Date Posted

23-May-2026

Closing Date

05-Jun-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.